keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LY2510924 acetate(1088715-84-7 free base) 是一种有效的选择性 CXCR4 拮抗剂。它可防止 SDF-1 与 CXCR4 结合,IC50 为 0.079 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,570 | 现货 | ||
5 mg | ¥ 3,120 | 现货 | ||
10 mg | ¥ 4,580 | 现货 | ||
25 mg | ¥ 7,280 | 现货 | ||
50 mg | ¥ 9,790 | 现货 | ||
100 mg | ¥ 13,200 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 7,190 | 现货 |
产品描述 | Ly2510924 acetate is an potent and selective CXCR4 antagonist. It prevents the binding of SDF-1 to CXCR4 with an IC50 of 0.079 nM. |
靶点活性 | CXCR4:0.079 nM |
体外活性 | In human lymphoma U937 cells expressing endogenous CXCR4, LY2510924 acetate inhibited SDF-1-induced cell migration with IC50 value of 0.26 nmol/L and inhibited SDF-1/CXCR4-mediated intracellular signaling. LY2510924 acetate exhibited a concentration-dependent inhibition of SDF-1-stimulated phospho-ERK and phospho-Akt in tumor cells. |
体内活性 | LY2510924 acetate showed dose-dependent inhibition of tumor growth in human xenograft models developed with non-Hodgkin lymphoma, renal cell carcinoma, lung, and colon cancer cells that express functional CXCR4. In MDA-MB-231, a breast cancer metastatic model, LY2510924 acetate inhibited tumor metastasis by blocking migration/homing process of tumor cells to the lung and by inhibiting cell proliferation after tumor cell homing. |
分子量 | 1250.49 |
分子式 | C64H91N13O13 |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (47.98 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 0.7997 mL | 3.9984 mL | 7.9969 mL | 19.9922 mL |
5 mM | 0.1599 mL | 0.7997 mL | 1.5994 mL | 3.9984 mL | |
10 mM | 0.08 mL | 0.3998 mL | 0.7997 mL | 1.9992 mL | |
20 mM | 0.04 mL | 0.1999 mL | 0.3998 mL | 0.9996 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
LY2510924 acetate(1088715-84-7 free base) Autophagy GPCR/G Protein Immunology/Inflammation CXCR LY2510924 acetate(1088715847 free base) LY2510924 acetate(1088715 84 7 free base) LY-2510924 acetate(1088715-84-7 free base) Inhibitor inhibitor inhibit